A fascinating property of the brain is that a large number of parameters, ranging from the size of synapses to the power of extracellular currents, follow right-skewed and heavy-tailed distributions. Understanding whether this organization is hard-wired or it progressively emerges throughout ontogeny is of great importance. Does developmental learning fundamentally alter the structure of the […]
In neonatal rodents, olfaction is already functional and more mature than the other senses. By silencing the outputs of olfactory bulb in the early postnatal days of mice, we found that the transient suppression of olfactory output led to a long-lasting reduction of oscillatory coupling in the downstream entorhinal-hippocampal networks and poor performance in cognitive […]
Check out our newest publication in the Journal of Physiology by Kostka & Hanganu-Opatz. We show that the neonatal olfactory bulb (OB) synchronizes the limbic circuity in the beta frequency range. Moreover, it drives neuronal and network activity in the lateral entorhinal cortex (LEC), as well as subsequently, hippocampus (HP) and prefrontal cortex (PFC) via […]
Check out our latest publication in The Journal of Physiology by Kostka and Hanganu-Opatz. We show that early activity in the olfactory bulb (OB) of neonatal mice, synchronizes the limbic circuity in the beta frequency range. Moreover, it drives neuronal and network activity in lateral enthorinal cortex (LEC), as well as subsequently, hippocampus (HP) and […]
Sebastian received the Du Bois-Reymond Prize of the German Physiological Society.
Steven and his colleagues investigated the molecular and cellular characteristics of maternal cells (short: MMc) that are transferred to the fetus during pregnancy. We showed that MMc seed the developing brain and influence the oscillatory entrainment of prefrontal-hippocampal circuits by altering microglia-induced synapse elimination. By this pathway, maternal cells contribute to the development of behavioral […]
Johanna and Sebastian are happy to announce the new paper: „Postnatal Development of Centrifugal Inputs to the Olfactory Bulb“. Johanna K. Kostka and Sebastian H. Bitzenhofer
on how E-I ratio and neuronal correlations change during early development!