Kategorie: Latest Publications

We are happy to share our latest publication in Brain, Behavior, and Immunity

Cognitive deficits in neuropsychiatric disorders arise from disrupted neuronal network activity, and growing evidence implicates neuroinflammation in this process, though the underlying mechanisms remain unclear. Using the Df(16)A mouse model of the human 22q11.2 microdeletion, we found that early postnatal mice display altered inflammatory signaling and increased microglial density in superficial layers of the prefrontal […]

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We are happy to announce our newest publication in Neuron

Calneuron-1 is a Ca2+ sensor that has been linked in several genome-wide association studies to schizophrenia (SCZ). We show that calneuron-1 expression is elevated in the dorsolateral prefrontal cortex of SCZ patients and that overexpression in the medial prefrontal cortex (mPFC) of mice elicits SCZ-related behavioral disabilities, disrupts rhythmogenesis within the mPFC, impairs functional connectivity between […]

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We are very excited about our new publication in ‚Science‘

A big shout out to Luna Jammal Salameh and Veronica Egger, who led this study, from University Regensburg. We show that heartbeat-induced pressure waves directly modulate the firing of a subset of neurons in the olfactory bulb (and other areas). These neurons increase their firing rate within ~20 ms after heartbeats, mediated by fast mechanosensitive [...]
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We are happy to share our latest publication on Current Biology

In neonatal rodents, olfaction is already functional and more mature than the other senses. By silencing the outputs of olfactory bulb in the early postnatal days of mice, we found that the transient suppression of olfactory output led to a long-lasting reduction of oscillatory coupling in the downstream entorhinal-hippocampal networks and poor performance in cognitive […]

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We are happy to announce our newest publication in The Journal of Physiology.

Check out our newest publication in the Journal of Physiology by Kostka & Hanganu-Opatz. We show that the neonatal olfactory bulb (OB) synchronizes the limbic circuity in the beta frequency range. Moreover, it drives neuronal and network activity in the lateral entorhinal cortex (LEC), as well as subsequently, hippocampus (HP) and prefrontal cortex (PFC) via […]

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Check out our latest publication in The Journal of Physiology by Kostka and Hanganu-Opatz. We show that early activity in the olfactory bulb (OB) of neonatal mice, synchronizes the limbic circuity in the beta frequency range. Moreover, it drives neuronal and network activity in lateral enthorinal cortex (LEC), as well as subsequently, hippocampus (HP) and […]

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Check out Mattia’s newest paper on eLife

Abstract Throughout development, the brain transits from early highly synchronous activity patterns to a mature state with sparse and decorrelated neural activity, yet the mechanisms underlying this process are poorly understood. The developmental transition has important functional consequences, as the latter state is thought to allow for more efficient storage, retrieval and processing of information. [...]
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Congratulation to Steven to the new publication in Nature Communications!

Steven and his colleagues investigated the molecular and cellular characteristics of maternal cells (short: MMc) that are transferred to the fetus during pregnancy. We showed that MMc seed the developing brain and influence the oscillatory entrainment of prefrontal-hippocampal circuits by altering microglia-induced synapse elimination. By this pathway, maternal cells contribute to the development of behavioral […]

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